附上两篇学术文献供参考
Oncogene (2008) 27, 200–207
Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer
R E Roses, M Xu, G K Koski and B J Czerniecki
Abstract
The identification of pathogen-associated molecular patterns, conserved microbial structures that act on Toll-like receptors, has led to a novel avenue of investigation aimed at developing a new generation of cancer immunotherapies. Ligation of Toll-like receptors results in the induction of robust immune responses that may be directed against tumor-associated antigens. Recent data suggest that such strategies may result in enhanced antitumor immunity. Nonetheless, as clinically effective immunotherapy for cancer remains a somewhat distant goal, attention has shifted toward multimodality approaches to cancer therapy, sometimes combining novel immune interventions and conventional treatments. The traditional view of radiation therapy as immunosuppressive has now been challenged, prompting a re-evaluation of its potential as an adjunct to immunotherapy. Radiation therapy can enhance the expression of tumor-associated antigens, induce immune-mediated targeting of tumor stroma, and diminish regulatory T cell activity. Recent evidence suggests that radiation therapy may also activate effectors of innate immunity through TLR-dependent mechanisms, thereby augmenting the adaptive immune response to cancer. In this paper, we will review evidence for enhanced tumor-directed immunity resulting from radiation exposure and early promising data suggesting synergistic effects of radiation and TLR-targeted immunotherapies.
摘译： 放疗能强化肿瘤相关抗原的表达，引起免疫介导的肿瘤基质标靶，减少调节性T细胞。最近的证据显示放疗还可通过陀样受体激活固有免疫，从而强化肿瘤适应免疫应答。
Int. J. Mol. Sci. 2014, 15, 927-943
The Effect of Radiation on the Immune Response to Cancers
Bonggoo Park, Cassian Yee and Kyung-Mi Lee,
Abstract: In cancer patients undergoing radiation therapy, the beneficial effects of radiation can extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors often leads to systemic responses at distant sites, a phenomenon known as the abscopal effect which has been attributed to the induction and enhancement of the endogenous anti-tumor innate and adaptive immune response. The mechanisms surrounding the abscopal effect are diverse and include trafficking of lymphocytes into the tumor microenvironment, enhanced tumor recognition and killing via up-regulation of tumor antigens and antigen presenting machinery and, induction of positive immunomodulatory pathways. Here, we discuss potential mechanisms of radiation-induced enhancement of the anti-tumor response through its effect on the host immune system and explore potential combinational immune-based strategies such as adoptive cellular therapy using ex vivo expanded NK and T cells as a means of delivering a potent effector population in the context of radiation-enhanced anti-tumor immune environment.
摘译： 局部放疗常导致远端肿瘤响应，归结为内源性抗肿瘤固有与适应免疫应答的导入和强化。 ......通过上调肿瘤抗原来强化肿瘤
的辨识与杀伤...... |
显身卡
