发给老马备查:/ _5 r! Y! O: R! @0 l
滴水察海(69304838) 15:23:23 2 t5 ^& K: z/ R0 `7 }' J老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 C$ c! p4 a" y6 S% F! d/ x& G
吉非替尼和S-1连用的依据0 o' g8 W9 E& T8 ], U, C
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.1 }# `* X' |& X/ @7 ?
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达+ o3 E0 g; H F7 N2 d1 w$ k/ f1 n. t
这样是不是推理出,耐药后,可以用S-1和培美了? ; G9 R) l0 B& y/ Q结论:" Z8 ^4 Q4 v+ M( W1 E; T- r
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。