Clovis Oncology (CLVS)宣佈，開始CO-1686（对付T790突变）臨床研究

老马，上面的英文可否找人翻一下？
最近得知有美国肺癌医生最看好两种药，其中一种就是你介绍的这个：CO-1686，另一种是PF00299804。PF已经有产品，CO-1686可否考虑上马？

对于耐药来说，这个药和WZ4002效果哪个更好呢？
现在看到坛子里面已经有人在使用WZ4002了 这个药可能还搞不到吧

那段英文的大意是：CO-1686的初始剂量是150mg，目前已经加量到1200mg每天，仍然没有观察到明显的副作用；由于它的半衰期短，所以1期的服用方案有每天1次，每天二次.每天三次。

http://seekingalpha.com/article/ ... ?source=google_news
This afternoon, I’d like to take the opportunity to highlight our clinical development programs CO-1686 and rucaparib in the context of 2012 accomplishments and anticipated 2013 milestones.
First to CO-1686, which is our oral small molecule covalent inhibitor of the mutant forms of epidermal growth factor receptor or EGFR for the treatment of non-small cell lung cancer. 1686 targets both the initial activating EGFR mutations, as well as the primary resistance mutation, T790M, and it has the potential to treat non-small cell lung cancer patients with EGFR mutations both as a first-line and a second-line treatment.
The CO-1686 spares wild-type or normal EGFR, it has the potential to cause a lower incidence of toxicity, particularly the skin rash and diarrhea normally associated with other EGFR inhibitors.
In March 2012, we initiated our first human clinical study in 1686. We initiated the Phase I/II study at a dose of 115 mgs per day given once daily and we recently initiated a dosing cohort at a dose of 900 milligrams two times daily.
Based on animal models and PK data, we believe that the cohorts that commenced dosing in late 2012 are now approaching the therapeutic window for 1686 to begin to show clinical benefit. In particular, we’re seeing trough plasma levels above the therapeutic threshold for a reasonable period of time, especially when the drug is given twice daily.

CO-1686的服用方案，目前看，是一天二次合适，血药浓度稳定。

http://www.inspire.com/groups/lu ... one-taking-co-1686/
By solozip
Reply 3694158
January 10, 2013 at 6:05 pm
i started the co-1686 trial on monday january 7, 2013 at stanford cancer center- i am the first in cohort 11 and am taking 400 mg 3 times a day for a total of 1200 mg- another cohort is taking same total dose but 600 mg 2 times a day at UCLA- after 27 hours i noticed a reduction in my coughing by about 60% - this continues through days 3 and 4 with my hope that it completely eliminates the cough in the next week or two - i have had NO side/adverse effects to this point- i am very active riding my bike and/or exercising every day- previous to this i had been on tarceva for about 13 months til some progression and the carboplatin and alimta for 6 cycles- the tarceva was great as i had no adverse effects and had even more than my usual energy- the carbo/alimta was not as effective and did cause my blood counts to go down , but i was able to keep up my exercise schedule but at a lower rate - i expect that there will be a report at the ASCO meeting in may/june about the progress of CO-1686- stay tuned for more updates in the future.
==================
gingers
Reply 3694315
January 10, 2013 at 7:10 pm
Report post
I had bad reaction. Not for me. I am T790 and had a flair.
Just found that I had almost complete response to carbo/taxol/avastin.:} I had horrible joint pain on co1686.
What I am trying to say is it sounds like it is working for you!!! Higher dose is great. I think no side-effects is super positive. Prayers are with you.
==================================
sharilou
Reply 3695474
January 11, 2013 at 8:15 am
Report post
stage IV EGFR+ NSCLC and resistant to Tarceva and afatinib.
Before CO-1686, I had a pleural effussion and had to have fluid removed twice within 10 days. After 6 weeks on the study drug, there was only a little left on the CT scan. All of my 6 week CT scans were stable even though I am T790M negative. I'm at 8 weeks now and can take a full breath with no coughing. Still no side effects...
=================================
By ConcordGal
Reply 3705691
January 14, 2013 at 6:17 pm
Report post
I began 400 mg three times a day for a total of 1200 mg of CO-1686 on December 26th. I have developed some severe back back which may, or may OT, be related to the drug. An MRI today revealed no mets, or other problems that would show up on an MRI. So, we are hoping it is a muscular issue that can be managed with a little pain meds, heat and rest. Still waiting for the genetic testing results to come back regarding the 790 mutation. My doctor thinks that will likely be positive. The good news is that, with the exception of the back pain, I have had no side effects from CO-1686. My skin, which was wrecked by Tarceva, is back to normal, as is my digestive tract. My first scan will be the 30th of January. We are all crossing our fingers.
================================
By sharilou
Reply 3707101
January 15, 2013 at 8:39 am
Report post
ConcordGal and solozip: Glad to hear the 1200 mg dose per day is going so well. I'm going to get my dose bumped up from 900 mg per day to 1200 mg if the group continues to do well. I'll be taking 600 mg twice a day. I'm in Detroit, Michigan @ Karmanos Cancer Center.
===============================================

期待这个药能有下文，让我们看到希望

学习了，感谢老马！

不知这个药现在的情况怎样? 有专利出来了吗?

学习了，期待这个药。