IL-2联褪黑素化疗后维持治疗结肠癌的，比没有维持治疗的提高了一年生存率，部分病人维持治疗时肿瘤继续退缩。
http://www.ncbi.nlm.nih.gov/pubmed/7715908
A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates.
Abstract
Chemotherapy with 5-fluorouracil (5-FU) and folates represents the first-line standard therapy for metastatic colorectal cancer, whereas at present there is no conventional second-time treatment. Because of its importance in generating an effective anticancer immune response, interleukin-2 (IL-2) could constitute a new promising therapy of advanced colon cancer. Generally, IL-2 may determine tumor regressions in colon cancer only when it is given at high toxic doses. Our preliminary studies have shown that the pineal hormone melatonin may amplify IL-2 activity, which becomes active also at low doses in several tumor histotypes. On the basis, we have performed a clinical trial to evaluate the impact of low-dose IL-2 plus melatonin on the survival time in metastatic colon cancer, which progressed in response to 5-FU plus folates. The study included 50 metastatic colorectal cancer patients, who did not respond or progressed after initial response to first-line chemotherapy with 5-FU and folates. Patients were randomized to receive supportive care alone or low-dose subcutaneous IL-2 (3 million IU/day for 6 days/week for 4 weeks) plus melatonin (40 mg/day orally). No spontaneous tumor regression occurred in patients receiving supportive care alone. A partial response was achieved in 3/25 patients treated with immunotherapy. Percent survival at 1 year was significantly higher in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05). This study suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates.
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肺腺癌10年，伏美替尼 心血管副作用
奶奶78岁，肺腺癌10年，2017.7-2023.7第一代靶向药凯美纳6年，2023.7至今伏美替尼1年
阿法替尼13个月，达克替尼5个月，目
2021年3月的最后一天，很平常的一天，一份CT报告打破了这平静的生活！也许再过一天，
求助，伏美替尼是在缓慢耐药吗？接下
基本情况
奶奶78岁，2014.7行肺腺癌手术，术后病理 浸润性肺癌，1.5*1.5cm，脏层胸膜
各位老师，帮忙看看我的问题，求帮助
父亲去年2023年2月份体检发现肺癌 晚期，免疫治疗一年，用药欧迪沃 期间病灶一直稳定
奥希替尼并非肺癌“万能解”，患者如
作者：Tony
在肺癌中，EGFR的突变以19号外显子缺失突变（19Del）和21号外显子的L858R
显身卡
