平安! 发表于 2011-11-9 19:57
+ R" | |8 _% @/ ^, o' RPazopanib (100 mg/kg/day free base equivalent) : i$ f e; h, B3 Q5 Z; |
这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。
, B& s; E& s% C搜索了一下,原料一大堆。8 B6 ?9 Y0 Q9 b( c+ S
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对不起!100mg/kg是用于移植瘤的,我弄错了。' _) p0 \+ l& O( J' j# j1 K7 N% [
. ]: x k& W4 ]) S3 X以下是正版说明书的推荐用量。% J" s2 j9 Y/ _8 h/ |% \
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--------------------- DOSAGE AND ADMINISTRATION ----------------
1 _5 N, |# w( B* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) / v/ J' E$ u% a1 W, Z4 ~
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2)
9 j! V6 I0 T! H9 o---------------------DOSAGE FORMS AND STRENGTHS --------------
/ I9 {7 s u: K8 t200 mg tablets. (3)
; M- ~6 c& A5 {! U* P3 a& ?-------------------------------CONTRAINDICATIONS------------------------ |