发给老马备查:2 o6 E/ l$ n6 ?" g3 L! `4 ~
滴水察海(69304838) 15:23:23% p5 [, u) e! a5 r+ B
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
. d4 F O& }% n9 i( S吉非替尼和S-1连用的依据
. x3 E" U3 [9 ]+ @# oGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
. _- i; ~% u5 Y# M: Q, t7 j/ }$ [* f4 ~) ]是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达( o. U3 w- ]9 o3 T6 u- y( I
这样是不是推理出,耐药后,可以用S-1和培美了?
s! C" Q, X; \1 N9 Q& Z/ U0 R结论:; m# Z0 {: X+ w- U$ t4 r- i A
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |