发给老马备查:0 U1 X5 j+ B% q7 s% ] M
滴水察海(69304838) 15:23:23
, C+ T! A0 b' X% L3 @! D% T% M' }老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
& D) U) X# x' c, N% g吉非替尼和S-1连用的依据9 c: |) L7 K7 P1 b% m
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
% Q. c/ ~& r( J( j3 d是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
0 E4 t# g( K! h这样是不是推理出,耐药后,可以用S-1和培美了?; h5 |) U4 \7 \7 s6 Q
结论:
& t8 S0 D$ E" {. Q2 A( I1 G如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |