发给老马备查:7 o" U7 n4 X4 s [$ F
滴水察海(69304838) 15:23:23 " v# C0 L* E" b9 O5 l2 }* H) I3 h老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱$ G( I1 c2 ` h) B0 m
吉非替尼和S-1连用的依据1 P1 [5 m; A$ U: n
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. ; O/ }# {* i2 i+ y是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达' t6 P4 W' c1 u! T
这样是不是推理出,耐药后,可以用S-1和培美了? $ ]$ E, D6 u4 b2 r" m x结论: + V" g7 w$ P' i+ _如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。